| I-20 | Interstate | Major east-west Interstate through the southern edge of Midland; major frontage-road reconstruction/interchange projects in the Midland/Odessa I-20 corridor. |
| SH-158 | State Highway | East–west state highway crossing Midland (through city and outskirts). Major widening/overhaul projects (e.g., Briarwood / CR-60 area). |
| Business SH-158-B | Business State Hwy | Old alignment/business route through sections of Midland (follows previous SH-158 routing). |
| SH-140 | State Highway | Short state route within Midland (Florida Ave / Garden City Hwy area) connecting Business SH-349-C to I-20/SH-158 interchange. |
| Loop 250 | State Loop | Northern/eastern bypass (freeway/divided sections) around Midland. |
| SH-349 / Business SH-349-C (Big Spring St / Andrews Hwy) | State Highway /Business | North–south route through Midland; parts signed as Business SH-349-C through town (Big Spring St). |
| SH-191 | State Highway | West–east route connecting the Odessa area into the Midland region (used as a relief corridor). |
| FM 307 | Farm-to-Market | Begins in the Midland area (Lamesa Rd / SH-158 area) and runs east ~17–18 miles (TxDOT designation file shows extents and minute orders). Frequently discussed for repaving/striping projects inside Greenwood / eastern Midland area. |
| FM 1379 | Farm-to-Market | Runs in/near Midland County and connects with SH-349 / SH-158 in the region; used as an east/west rural connector from the southern/eastern parts of the county toward Midland. |
| FM 3503 | Farm-to-Market | Straddles Ector & Midland counties; TxDOT file lists it running between IH-20 (Odessa) and FM-1788 (south of Midland) — portions are in the Midland area and have had planned realignments. |
| FM 1788 | Farm-to-Market | Connects to I-20 / SH-191 area and serves the southern Midland/adjacent growth corridors; appears on county road maps and project pages. |
| FM 1357, FM 3095, FM 1213, FM 715 | Farm-to-Market | Several other FM routes appear on the Midland County road map and/or state route lists and either run into Midland city limits or terminate very near city limits (FM-715 is specifically noted as in Midland County connecting SH-140 south to FM-1213). |